Choosing the wrong inference serving framework can cost your organization 40-60% more in infrastructure spend while delivering 3x worse latency. With production LLM deployments requiring massive GPU resources, the difference between vLLM’s PagedAttention and default PyTorch memory management alone can determine whether your model fits on an A100 or requires an H100 cluster. This guide provides a comprehensive cost and performance comparison of the four leading open-source inference serving frameworks: vLLM, TorchServe, Ray Serve, and Text Generation Inference (TGI).
In production environments, inference serving infrastructure determines your cost-per-token more than any other factor. While model pricing from providers like OpenAI or Anthropic is straightforward, self-hosting requires navigating hardware costs, memory efficiency, throughput optimization, and operational overhead.
The stakes are significant:
GPU Memory: A 70B parameter model requires ~140GB in FP16. Framework memory optimization can reduce this to 35-70GB through quantization and KV cache management, enabling deployment on fewer GPUs.
Throughput: Frameworks with continuous batching can process 3-5x more requests per GPU-hour than naive implementations, directly impacting cost-per-inference.
Latency: Optimized kernels (FlashAttention, PagedAttention) can reduce time-to-first-token by 30-50%, critical for user-facing applications.
According to Google Cloud’s best practices for LLM inference on GKE, proper framework selection and configuration can reduce total cost of ownership by 50% or more while improving performance docs.cloud.google.com.
vLLM has emerged as the dominant open-source serving framework due to its PagedAttention mechanism, which manages attention key and value caches like virtual memory paging. This approach eliminates memory fragmentation and enables continuous batching of requests.
Key Advantages:
Continuous Batching: Automatically batches incoming requests without waiting for batch completion, improving GPU utilization by 2-3x
TorchServe, developed by PyTorch and AWS, provides a production-ready serving solution with robust model management, versioning, and A/B testing capabilities. While less specialized for LLMs than vLLM, it offers enterprise-grade features.
Key Advantages:
Model Versioning: Built-in support for multiple model versions and traffic splitting
Custom Handlers: Flexible lifecycle management for preprocessing, inference, and postprocessing
Metrics Integration: Native Prometheus support for monitoring
Enterprise Ecosystem: Strong integration with AWS and enterprise MLOps tools
Best For: Organizations requiring strict model governance, A/B testing, and integration with existing PyTorch ecosystems.
Ray Serve is part of the Ray ecosystem, designed for building distributed applications with dynamic scaling. It excels at serving multiple models and handling variable traffic patterns through autoscaling.
Key Advantages:
Dynamic Scaling: Autoscales replicas based on traffic patterns
Multi-Model Serving: Can serve multiple models from a single deployment
Composition: Supports complex inference pipelines with multiple stages
Distributed Architecture: Native support for multi-node deployments
Best For: Complex inference pipelines, multi-model serving, and applications with highly variable traffic.
Text Generation Inference (TGI): The Production-Optimized Solution
TGI, developed by Hugging Face, is purpose-built for text generation with optimized kernels and production features like streaming, token-level timeouts, and production-ready metrics.
Key Advantages:
Optimized Kernels: FlashAttention and custom CUDA kernels for maximum performance
Streaming Support: Native Server-Sent Events (SSE) for real-time streaming
Production Features: Built-in health checks, metrics, and request timeouts
Quantization: Native support for bitsandbytes, AWQ, and GPTQ
Best For: Production deployments requiring streaming, maximum performance, and minimal configuration overhead.
vLLM and TGI lead in throughput due to continuous batching and optimized attention kernels, delivering 1.5-2x the RPS of TorchServe and Ray Serve for the same hardware.
Memory efficiency is critical: vLLM and TGI achieve 85-92% utilization vs. 70-80% for others, potentially reducing hardware requirements by one GPU tier.
Latency consistency: TGI and vLLM show more consistent p50/p99 latency ratios due to better request scheduling.
Determine your model size, expected QPS (queries per second), and context length requirements. For models greater than 30B parameters, prioritize frameworks with strong tensor parallelism (vLLM, TGI). For variable traffic, consider Ray Serve’s autoscaling.
Select Hardware Configuration
Based on throughput needs:
Low volume (less than 10 RPS): Single A100 40GB with any framework
Medium volume (10-100 RPS): A100 80GB with vLLM or TGI
High volume (greater than 100 RPS): H100 or multi-GPU setup with vLLM/TGI
Use memory calculators: 7B model ≈ 14GB FP16, 70B model ≈ 140GB FP16.
Deploy with Optimized Configuration
Implement the framework with production best practices:
Enable continuous batching (vLLM, TGI)
Configure GPU memory utilization (0.85-0.95)
Set appropriate max sequence lengths
Implement health checks and readiness probes
Configure horizontal pod autoscaling for traffic spikes
Not enabling continuous batching: vLLM and TGI support continuous batching by default, but TorchServe and Ray Serve require explicit configuration. Without it, you’ll process requests sequentially, reducing throughput by 60-70%.
Ignoring GPU memory utilization: Setting gpu_memory_utilization too low (default is often 0.9) wastes capacity. For production, set to 0.95-0.98, but always leave 2-4GB for system processes.
Overlooking max_model_len: Failing to set max_model_len appropriately can cause OOM errors with long contexts. Set it to your actual maximum context length, not the model’s theoretical maximum.
Missing tensor parallelism for large models: Attempting to load a 70B model on a single GPU without tensor parallelism will fail. Use tensor_parallel_size=N where N is the number of GPUs needed.
No health checks in production: Kubernetes deployments require proper liveness/readiness probes. Without them, failed containers won’t restart automatically.
Failing to configure quantization: For memory-constrained environments, not using FP8/INT4 quantization means you can’t deploy larger models, forcing you to use smaller, less capable models.
Ignoring prefix caching for RAG: RAG applications with repetitive system prompts benefit massively from prefix caching (vLLM, TGI). Not enabling it wastes 20-40% of compute on redundant context processing.
Single replica deployments: Without horizontal scaling, traffic spikes will cause request queuing and latency spikes. Always configure HPA based on GPU utilization or queue depth.
Not monitoring queue depth: Frameworks expose queue depth metrics. Ignoring these leads to blind spots when requests are being queued rather than processed immediately.
Using default batch sizes: Default batch sizes are often conservative. Benchmark your specific model and hardware to find optimal max_batch_size and max_batched_tokens.
In production environments, inference serving infrastructure determines your cost-per-token more than any other factor. While model pricing from providers like OpenAI or Anthropic is straightforward, self-hosting requires navigating hardware costs, memory efficiency, throughput optimization, and operational overhead.
The stakes are significant:
GPU Memory: A 70B parameter model requires ~140GB in FP16. Framework memory optimization can reduce this to 35-70GB through quantization and KV cache management, enabling deployment on fewer GPUs docs.cloud.google.com.
Throughput: Frameworks with continuous batching can process 3-5x more requests per GPU-hour than naive implementations, directly impacting cost-per-inference.
Latency: Optimized kernels (FlashAttention, PagedAttention) can reduce time-to-first-token by 30-50%, critical for user-facing applications.
According to Google Cloud’s best practices for LLM inference on GKE, proper framework selection and configuration can reduce total cost of ownership by 50% or more while improving performance docs.cloud.google.com.
This production-ready example demonstrates vLLM’s continuous batching, which automatically processes incoming requests without waiting for batch completion. The enable_prefix_caching=True parameter is particularly valuable for RAG applications, where system prompts are frequently reused docs.vllm.ai.
For TGI deployments, the framework includes optimized kernels like FlashAttention for improved performance on NVIDIA GPUs huggingface.co. The following bash script shows a production deployment with health checks:
TGI Production Deployment Script
#!/bin/bash
# Production TGI deployment script with health checks
MODEL_ID="meta-llama/Llama-3.2-1B-Instruct"
PORT=8080
MAX_TOTAL_TOKENS=4096
MAX_BATCH_PREFILL_TOKENS=2048
# Check GPU availability
if ! command -v nvidia-smi &> /dev/null; then
echo "Error: nvidia-smi not found. NVIDIA GPU required."
exit 1
fi
# Check if model is already running
if docker ps --filter "name=tgi-server" --format "{{.Names}}" | grep -q "tgi-server"; then
if curl -s http://localhost:$PORT/health > /dev/null 2>&1; then
echo "TGI server is ready!"
echo "Test with:"
echo "curl -X POST http://localhost:$PORT/generate -H 'Content-Type: application/json' -d '{"inputs": "What is the capital of France?", "parameters": {"max_new_tokens": 50}}'"
exit 0
fi
sleep 2
done
echo "Error: TGI server failed to start within 120 seconds"
Not enabling continuous batching: vLLM and TGI support continuous batching by default, but TorchServe and Ray Serve require explicit configuration. Without it, you’ll process requests sequentially, reducing throughput by 60-70%.
Ignoring GPU memory utilization: Setting gpu_memory_utilization too low (default is often 0.9) wastes capacity. For production, set to 0.95-0.98, but always leave 2-4GB for system processes.
Overlooking max_model_len: Failing to set max_model_len appropriately can cause OOM errors with long contexts. Set it to your actual maximum context length, not the model’s theoretical maximum.
No tensor parallelism for large models: Attempting to load a 70B model on a single GPU without tensor parallelism will fail. Use tensor_parallel_size=N where N is the number of GPUs needed docs.cloud.google.com.
No health checks in production: Kubernetes deployments require proper liveness/readiness probes. Without them, failed containers won’t restart automatically.
Failing to configure quantization: For memory-constrained environments, not using FP8/INT4 quantization means you can’t deploy larger models, forcing you to use smaller, less capable models docs.cloud.google.com.
Ignoring prefix caching for RAG: RAG applications with repetitive system prompts benefit massively from prefix caching (vLLM, TGI). Not enabling it wastes 20-40% of compute on redundant context processing.
Single replica deployments: Without horizontal scaling, traffic spikes will cause request queuing and latency spikes. Always configure HPA based on GPU utilization or queue depth.
Not monitoring queue depth: Frameworks expose queue depth metrics. Ignoring these leads to blind spots when requests are being queued rather than processed immediately.
Using default batch sizes: Default batch sizes are often conservative. Benchmark your specific model and hardware to find optimal max_batch_size and max_batched_tokens.